Scientists unveil a giant leap forward in anti-aging – NAD+, short for Nicotinamide Adenine Dinucleotide

UNSW researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.

In a paper published in Science Today, the team identifies a critical step in the molecular process that allows cells to repair damaged DNA.

Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes this new discovery can help its mission to Mars program.

While our cells have an innate capability to repair DNA damage—which happens every time we go out into the sun, for example – their ability to do this declines as we age.

The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair.

Treating mice with a NAD+ precursor, or “booster,” called NMN was shown to improved their cells’ ability to repair DNA damage caused by radiation exposure or old age.

“The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,” said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.

Human trials of NMN therapy began in the Fall of 2017.

“This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well,” says Sinclair, who maintains a lab at UNSW in Sydney.

Dr. Sinclair NAD+ discovery
Dr. David Sinclair, Harvard Medical School

The work has excited NASA, which is currently focused on the challenge of keeping its astronauts healthy during a four-year mission to Mars.

Even during short missions, astronauts experience accelerated ageing from cosmic radiation, suffering muscle weakness, memory loss and other symptoms when they return. On the journey to Mars, the situation would be far worse: five per cent of the astronauts’ cells would die and their chances of cancer would approach 100 per cent.

Professor Sinclair and his UNSW colleague Dr. Lindsay Wu were winners in NASA’s iTech competition in December last year because of their discovery of NAD+’s role in DNA repair.

“We came in with a solution for a biological problem and it won the competition out of 300 entries,” Dr. Wu says.

Professor David Sinclair and his UNSW team.

Cosmic radiation is not only an issue for astronauts. We’re all exposed to it aboard commercial aircraft, with a London-Singapore-Melbourne flight roughly equivalent in radiation to a chest x-ray.

In theory, the same treatment could mitigate any effects of DNA damage for frequent flyers.The other group that could benefit from this work is survivors of childhood cancers.

Dr. Wu says 96 per cent of childhood cancer survivors suffer a chronic illness by age 45, including cardiovascular disease, Type 2 diabetes, Alzheimer’s disease, and cancers unrelated to the original cancer.

“All of this adds up to the fact they have accelerated ageing, which is devastating,” he says.
“It would be great to do something about that, and we believe we can with this molecule, NAD+”

For the past four years, Professor Sinclair and Dr. Wu have been working on making an NMN-based pharmaceutical drug with their companies MetroBiotech NSW and MetroBiotech International.

Human trials have begun this year at Brigham and Women’s Hospital, in Boston.

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